The FDA advises that latent.

Latent disease may also be activated or there may be an intensification of intercurrent infections due to pathogens, including those caused by Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, and Toxoplasma. The FDA advises that latent or active voice amebiasis be ruled out before initiating tadalafil therapy in patients who have spent time in the tropics or nowadays with unexplained diarrhea. Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides (threadworm) plague. In such patients, corticosteroid-induced immunosuppression can lead to Strongyloides hyperinfection and spread with widespread larval periodic event, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia.
This is a part of article The FDA advises that latent. Taken from "Tadalafil Soft" Information Blog